We might all known the fact that microorganisms get killed by dry heat due to the oxidation effects.

Direct Flaming.
Direct flaming designates one of the most simple method of dry-heat sterilization. In reality, the dry-heat sterilization is mostly used in a ‘microbiology laboratory’ for the sterilization of the ‘inoculating loops’, which is duly accomplished by heating the loop wire to a ‘red glow’, and this is 100% effective in actual practice. Likewise, the same principle is even extended to the process of ‘inceneration’ to sterilize as well as dispose of heavily contaminated paper bags, cups, and
used dressings.
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Application of pharmaceutical principles to drug dosage forms is illust rated when drug dosage forms are categorized according to their physical state, degree of heterogeneity, and chemical composition. The usual relevant states of matter are gases, liquids, and solids. Intermolecular forces of attraction are weakest in gases and strongest in solids. Conversions from one physical state to another can involve simply overcoming intermolecular forces of attraction by adding energy (heat) . Chemical composition can have a dramatic effect on physicochemical properties and behavior. For this reason, it is necessary to distinguish between polymers, or macromolecules, and more conventional ( i .e., smaller) molecules, or micromolecules.
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