There are three most prominent ‘genetic methods’ that are invariably employed for the methodical
arrangement of microbes based upon various taxonomic groups, namely:
(i) Genetic relatedness
(ii) The intuitive method, and
(iii) Numerical taxonomy.
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Application of pharmaceutical principles to drug dosage forms is illust rated when drug dosage forms are categorized according to their physical state, degree of heterogeneity, and chemical composition. The usual relevant states of matter are gases, liquids, and solids. Intermolecular forces of attraction are weakest in gases and strongest in solids. Conversions from one physical state to another can involve simply overcoming intermolecular forces of attraction by adding energy (heat) . Chemical composition can have a dramatic effect on physicochemical properties and behavior. For this reason, it is necessary to distinguish between polymers, or macromolecules, and more conventional ( i .e., smaller) molecules, or micromolecules.
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Paleopharmacological studies attest to the use of medicinal plants in pre-history.
The earliest known compilation of medicinal substances was ARIANA the Sushruta Samhita, an Indian Ayurvedic treatise attributed to Sushruta in the 6th century BC. However, the earliest text as preserved dates to the 3rd or 4th century AD.

Many Sumerian (late 6th millennium BC – early 2nd millennium BC) cuneiform clay tablets record prescriptions for medicine.
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